A cassette containing an IRES, human AFP and polyadenylation signal was inserted into the 3' untranslated region along with a floxed neo cassette and resulted in a duplication of exon 13 through part of exon 18. The neo cassette was removed by transient cre expression. Expression of AFP was confirmed by a quantitative immunoassay. (J:132096)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Insertion, Other
--
1
10
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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