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The upstream recombination signal sequence (RSS) was replaced by a loxP flanked neomycin resistance gene. Founder mice were crossed with a transgenic mouse that expresses Cre in germline cells for the removal of the neomycin cassette. Genomic PCR and sequencing confirmed the 139 bp encompassing the RSS were replaced by 190 bp consisting of a loxP site flanked by vector sequence. (J:132125)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
