2.2 kb downstream of exon 13 a thymidine kinase and a floxed hygromycin cassette, both in reverse transcriptional orientation, were inserted into the genomic sequence. These modifications were performed in an ES cell line in which Cyp3a57 had already been targeted. (J:127366)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count