An frt-flanked neo cassette with a 5' loxP site was inserted into intron 2 and an additional loxP site was inserted into intron 4. The neo cassette was removed by germ-line flp-mediated recombination to leave exons 3 and 4 floxed. (J:131699)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count