An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. The neo cassette was subsequently removed by germ-line, flp-mediated recombination to yield a floxed exon 3. (J:130825)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count