A cassette containing a splice acceptor, frt-flanked neo cassette, floxed IRES-EGFP with a farnesyl modification, and human placental alkaline phosphatase was inserted into the ROSA locus. Expression of the membrane-bound EGFP occurs after flp-mediated excision and expression of the human placental alkaline phosphatase occurs after both flp- and cre-mediated recombination. (J:128980)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count