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The endogenous gene was replaced with one in which the three Runx1 binding sites within a floxed upstream regulatory element (URE) were mutated from TGTGGT to TGACCT by sire-directed mutagenesis. A frt-flanked neo cassette was inserted upstream of the URE. (J:131217)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
