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The Itgax promoter drives dendritic cell-specific expression of a floxed cassette that contains the SV40 T-antigen gene with an inserted initiation site, an inserted perfect Kozak sequence and removal of the 5' and 3' untranslated regions followed by an IRES-EGFP reporter. The intron and polyadenylation signal of rabbit beta1 globin with a 3' frt site is located between the promoter and floxed cassette. Production of multiple transgene splice products was confirmed by RT-PCR on spleen extracts. (J:131319)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
