Chimeric males with the floxed region were crossed to cre-expressing females and exons 1 through 5 were removed in the germ line. The absence of transcript was confirmed by northern blot analysis on E10.5 embryos extracts. (J:131268)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count