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The following sequences were inserted in the 3' UTR in exon 11: an IRES, the human diphtheria toxin receptor (HBEGF) cDNA coding region in-frame with the EGFP gene coding region, a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site. Cre-mediated self-excision removed the cre+neo cassette in the male germline. The presence of the EGFP cassette does not interfeer with expression of the gene locus. EGFP expression occurs in Foxp3+ regulatory T cells. (J:131351)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
