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A variable heavy chain gene segment belonging to the VH558 family along with 1.3 kb of upstream sequence and 500 bp of downstream sequence was knocked into a region of the IgH complex that lies 500 bp upstream of the most proximal D segment, DFL16.1. A loxP-flanked neomycin targeting cassette included in the targeting was subsequently removed by crossing chimeric mice with Cre expressing transgenic mice. Targeting events were confirmed through Southern blotting and restriction mapping. (J:130421)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
