Pbx3^tm1.1Og

A neo cassette with a 5' loxP site was inserted into intron 3 and an additional loxP site was inserted into intron 2. Targeting took place in PC3 ES cells homozygous for Tg(Prm-cre)70Og. Cre-recombinase under control of the male-germline specific protamine promoter resulted in the removal of exon 3 upon transmission from male chimeras. The authors state that this is a null allele. (J:130927)