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A floxed neo cassette and an exon 17 carrying a nucleotide substitution that results in an amino acid substitution of tyrosine for aspartic acid at position 818 (D818Y) was knocked into the open reading frame. The neo cassette was subsequently removed by germ-line, cre-mediated recombination. (J:130890)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
