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A polyA based transcriptional stop element was inserted 1.5-kb downstream of the transcription start and a self-excising selection cassette was placed downstream of the gene. After recombination and generation of chimeric mice, the selection cassette excised itself in the male germline leaving behind the stop element and a single loxP site. Heterozygous mice that inherit the deletion paternally transcribe a truncated RNA that is missing the distal 58.5 kb of sequence. (J:108700)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
