A floxed neo cassette and loxP site were introduced into intron 3 and intron 6, respectively, via homologous recombination. In vivo cre-mediated recombination removed the neo cassette, leaving exons 4 - 6 flanked by loxP sites. (J:129967)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count