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Exon 4 was floxed by introducing a loxP site upstream of the exon and inserting a loxP flanked PGK/TK neomycin cassette downstream of the exon. Chimeric mice were generated, crossed with a Cre-deleter strain and offspring were selected that had both exon 4 and the neo selection cassette removed. The deletion was also predicted to generate a frameshift mutation with a premature stop codon. Gene inactivation was confirmed by Western blot analysis of liver and testis protein. (J:130210)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
