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A loxP site was inserted about 1kb upstream of exon 1 and a loxP-flanked neo selection cassette was inserted into intron 1. Transient transfection of Cre-recombinase deleted the genomic sequence encoding part of the promoter, the upstream untranslated region of the gene, exon 1 which contains the ATG site and part of the coding sequence for the signal peptide, and a portion of intron 1. A single loxP site remained in place of the deleted gene sequence. Gene inactivation was confirmed by Northern and Western analysis of small intestine tissue. (J:130258)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
