RMCE using Ptf1atm1Mgn inserted a cre and mouse Esr1 (CreERTM) replacing exon 1 and 2 and a hygromycin resistance cassette downstream of exon 2. Flp-mediated recombination removed the FRT-flanked hygro cassette. (J:180310, J:194063)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count