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The 1.1 kb human NFKBIA cDNA with two introduced point mutations at codons 32 and 36 (resulting in amino acid changes S32A and S36A) was subcloned between the 5.5 kb alpha-myosin heavy chain promoter and the 736 bp human growth hormone (Hgh) polyadenylation signal. Five founders with 1, 2 (line 17), 7 (line 44), 4 (line 151), and 7 (line 159) copies of the transgene were identified, but no offspring from the single copy number founder were obtained. (J:102613)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
