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The rat insulin 2 promoter was used to drive expression of the gene in beta cells. Chrm3 contains two modifications (an N-terminal 9 amino acid hemagglutinin epitope tag was added and a central portion of the third intracellular loop, Ala274 to Lys469, was deleted) that do not change its functionality but allow the researchers to distinguish it from the endogenous gene product. (J:129643)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
