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A 15-kB genomic fragment containing the entire human renin gene and including 3Kb of 5' flanking region and 3'flanking region was used to create transgenic mice. Copy number is estimated to be 2 or more. High levels of mRNA encoding human renin are found in transgenic mouse kidney, and significant levels are detected in brain, lung, thymus, testis and spleen. Low levels are detectable in heart, pancreas and stomach. In addition to line 8-12, lines 8-3 and 8-5 were also created, but these lines express at lower levels than line 8-12. (J:129503)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
