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The transgenic construct contains a GFAP promoter used to drive the expression of a cDNA encoding the human wild-type amyloid precursor protein (695 isoform). In this transgenic mouse line, human APP protein is expressed in astroglia. Another line, line gae-III (GFAP-ApoE4 line 3) was also established. (J:128837)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
