A rat Creb1 cDNA was mutated at codon 133 to alter the endcoded serine to an alanine. In addition, a FLAG-tag peptide was added at the N-terminus to distinguish the expressed protein from the endogenous protein. The modified cDNA was cloned into an expression vector containing a tetracycline responsive element (TetOP) and a CMV minimal promoter. (J:128620)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count