A targeting construct was used to flank exons 8 to 13 with loxP sites and insert an FRT-flanked NEO cassette into intron 13. The loxP flanked region is designed to remove amino acids 361 to 692, which encompasses a part of armadillo repeat 6 to a part of the C terminus. (J:232771)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count