A floxed neo cassette was inserted upstream of exon 5 with an additional loxP site inserted downstream of exon 5. Cre-mediated recombination using a transiently transfected pMC-Cre vector was used to remove the neo cassette. (J:128523)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count