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The transgene contains a BAC in which the Ascl1 open reading frame is replaced with a cre-estrogen response element fusion. Expression of cre, detected following a cross to a reporter strain, is restricted to the midbrain at E10.5, the developing sympathetic neurons at E10.5 and E11.5, the enteric nervous system, diencephalon and hindbrain at E11.5, and the dorsal neural tube at E12.5 reflecting the endogenous expression pattern of the gene. Two lines were established (B2C-6 and B2C-8). B2C-6 was analyzed in more detail and is represented by line 1 here. (J:117032)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
