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The sequences of the variable regions of the TCR alpha and beta chains of the R28 hybridoma with rearranged Va4Ja27 and Vb6Jb1.5 genomic DNA fragments were amplified and cloned into TCR expression cassettes. Transgene-derived clones are transcribed under the control of the natural TCR alpha and -beta promoter/enhancer elements. A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of Ak. (J:36815)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
