Sell^tm2Alb

The Sell gene was disrupted by insertion of a puromycin resistance cassette in opposite orientation into the coding sequence via homologous recombination. The construct was injected into ES cells already carrying mutations in Sele and Selp. Clones where the targeting vector inserted in cis to the Sele and Selp mutations were used to produce triple selectin-null mutant mice. (J:70682)