A beta-geo gene trap vector inserted into intron 1. Western blot analysis confirmed the absence of protein expression in extracts from primary fibroblasts. In primary fibroblasts levels of phophatidylinositol 3,5-biphosphate and phophatidylinositol 5-phosphate are significantly reduced while levels of phophatidylinositol 3-phosphate are elevated. (J:127106)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count