Log In|Sign Up
EN
The Thy1-APPKM670/671NL was constructed with the mutant human APPKM670/671NL cDNA (Swedish or KM670/671NL mutation of amyloid precursor protein (APP)) placed downstream of the murine Thy1.2 promoter region. Additionally, the Thy1-PS1L166P transgene was constructed with a mutant human PS1L166P cDNA (leucine to proline mutation at position 166 of human presenilin 1 (Alzheimer disease 3, PSEN1 or PS1)) placed downstream of the murine Thy1.2 promoter sequences. These constructs were coinjected to produce founder mice. In addition to line 21, lines 5 and 8 were also established. (J:116895)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
