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One loxP site was inserted into intron 13 and the other, with a PGK-neo cassette, into intron 14. Exon 14 was excised by Cre mediated recombination, resulting in a nonsense frame-shift mutation. Excision of the exon was confirmed by RT-PCR and sequencing analysis of mRNA isolated from the large intestine. Western blot detected the truncated product (70 kDa). (J:127452, J:156864)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
