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The coding region was replaced with a coding region containing substitution that results in an amino acid substution of a glutamine for an arginine at position 43 (R43Q), 4 aditional silent mutations (not identified) and a floxed neo cassette that was subsequently removed by cre-mediated recombination. Expression levels were confirmed to be normal by RT-PCR analysis on total brain extracts. Reduction in protein product was confirmed by wesrtern blot analysis on extracts from E16 forebrains. This allele was generated from Gabrg2tm2Spet. (J:127120)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
