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A targeting vector was designed to insert an frt-flanked pGK-Neo cassette 468 bp upstream of the miR-150 stem loop, with one loxP site placed immediately upstream of the pGK-Neo cassette and the other loxP site placed 146 bp downstream of the miR-150 stem loop. To delete the loxP site-flanked 679 bp miR-150 coding genomic region and the frt-flanked pGK-Neo cassette, mice were then bred to cre-expressing mice (C57BL/6 congenic background, similar to Stock No. 006054). The resulting mice have a single loxP site replacing the miR-150 coding region. (J:127234)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
