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A targeting vector was designed to flank exon 3 of the gene with loxP sites and insert a FRT-flanked neomycin resistance cassette in intron 3 (within the loxP sites). Resultant carrier mice were crossed with a germline Cre transgenic strain driven by a protamine 1 (Prm1) promoter on a mixed C57BL/6 and 129 background to remove both exon 3 and the neomycin cassette. (J:134026, J:216293)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
