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A targeting vector introduced a cysteine (TGC) to alanine (GCG) substitution at amino acid position 373 (C373A) encoded within exon 8. A loxP flanked pGKNeo cassette was removed by crossing mice with Cre-transgenic mice, leaving behind a single loxP site. Western analysis of bone marrow derived mast cells from homozygotes indicated protein expression was similar to wild-type protein. (J:126361)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
