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Serines 831, 839, 845 and threonines 838 and 840 were mutated to alanine by PCR mutagenesis prior to homologous recombination. A floxed neo cassette was inserted upstream of the last conding exon was removed by cre-mediated recombination following a cross to mice containing Tg(CMV-cre)1Nagy. Western blot analysis with was performed to confirm the presence of the protein but loss of the phosphorylation sites. (J:126784)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
