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The transgene contains the tet operator, tetO, regulating expression of a dominant negative N-ethylmaleimide-sensitive factor attachment protein receptor, or SNARE (dn-SNARE), that blocks the release of neurotransmitters. dn-SNARE is the cytosolic part of the SNARE domain (amino acids 1-96) of vesicle-associated membrane protein 2 (VAMP2; formerly synaptobrevin II). The enhanced green fluorescent protein (EGFP) and E. coli beta-galactosidase (lacZ) reporter genes are also expressed under the control of tetO. The three constructs were co-injected. (J:102245)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
