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A floxed neo cassette was inserted into the 5' untranslated region and an additional loxP site was inserted downstream of exon 1. Cre-mediated recombination by transient expression of cre deleted the exon 1. which contains the initiation methionine and a transmembrane domain. Without the signal peptide and the transmembrane domain no functional protein is made. The lack of transcript was confirmed by RT-PCR. (J:126687)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
