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Cre-mediated recombination was used to remove the floxed fragment containing a cDNA that encodes amino acids 219 to 376 and a neo cassette leaving behind a modified exon 7 with a stop codon and polyadenylation site. This removed the UIM domains from the protein. PCR genotyping was used to confirm the removal of the cDNA fragment and neo cassette. (J:126546)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
