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These mice were generated by producing animals carrying the Evx2/Hoxd1tm4Ddu allele and another targeted Hoxd allele Hoxdtm5Ddu which has a loxP site between Hoxd11 and Hoxd10. Cre recombinase was introduced via the Tg(Sycp1-cre)4Min transgene, resulting in a crossing over between the loxP sites in the two alleles during meiotic prophase, inducing deletion of Hoxd11, Hoxd12, and Hoxd13. The Hoxd11/cre sequence is now located in the original genomic position of the deleted endogenous Hoxd11 locus. (J:82530)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
