A loxP site was inserted upstream of an exon encoding the entire reading frame and a frt-flanked neo cassette was inserted downstream of the exon. The neo cassette was removed by Flp-recombinase activity following a cross to Tg(ACTFLPe)9205Dym mice. (J:126082)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count