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A cre recombinase gene optimized for mammalian codon usage was inserted right after the ATG of exon 1 in a human BAC, which was then injected into oocytes. Insertion of the cre gene was confirmed by PCR on genomic DNA. Cre expression is restricted to all epidermis MHC-II+CD11c+ Langerhans cells but not other CD207 expressing cells. (J:126147)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
