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Exon 7 was removed by cre-mediated recombination and results in an out of frame translation. The absence of a wild-type allele in mouse embryonic fibroblasts was confirmed by RT-PCR using primers located in exon 6 and 9. However, higher levels of an alternative splice form without exons 7 and 8, which is missing the TRAF2 and NEMO binding sites, are produced. (J:126113)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
