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An IRES-lacZ-PGK-neo cassette was inserted between exons 17 and 19 replacing exon 18 and its surrounding intronic sequences. Sequences encoding the first six transmembrain domains are replaced. The predicted protein is fused to a beta-galactosidase peptide and lacks the endogenous transmembrane and cytoplasmic domains. The absence of protein product was confirmed by western blot analysis on protein extracts from embryonic endothelioma cells established from E9.5 mice. (J:125783)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
