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The OmniBank gene trap vector was inserted at position -3,273 to -3,272 relative to the ATG start site. Insertion disrupts the function of the distal promoter as confirmed by RT-PCR. Disruption of protein expression levels was confirmed by western blot analysis wich revealed a 50-75% reduction in the skeletal muscles, little change in the heart and a 99% reduction in the brain. (J:125530)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
