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The transgene contains the mouse mammary tumor virus long terminal repeat (MMTV LTR) driving expression of cytochrome P450, family 21, subfamily a, polypeptide 1 (Cyp21a1) from a 3.9-kb genomic DNA segment containing the Cyp21a1 gene and ~700 kb of 5' flanking DNA isolated from a cosmid library of B10.A-H2/SgSnJMis genomic DNA. In this line, 7-10 copies of the transgene were estimated by Southern blot analysis to have integrated into a single site on Chr 17, approximately 10 cM from the endogenous Cyp21a1 gene. (J:20978)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
