A lacZ-3pA with a nuclear localization signal and a floxed PGKneo cassette were inserted into exon 1 to create a null allele. Removal of the cre cassette was achieve via a cross to mice carrying the Hprt1tm1(cre)Mnn allele. Absence of transcript was confirmed by RT-PCR on homozygous mice. LacZ expression was confirmed by X-gal staining. (J:125184)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6J)F1
Targeted
Insertion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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