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A gene trap vector containing the beta-geo cassette was inserted into the intron between exons 6 and 7 creating a truncation. Insertion of the gene trap was confirmed by PCR and Southern blot analysis. Disruption in protein expression was confirmed by western blot. Maternal expression in peripheral tissues such as fat, muscle, liver, pancreas, heart, lung, kidney and spleen is disrupted by insertion of the gene trap. However, paternally inherited expression in the brain is unaffected. (J:125128)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
