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The construct consisted of the sequence expressing human alpha-synuclein 1-120 which is truncated, lacking the final 20 amino acids inserted downstream of the rat tyrosine hydroxylase promoter Th in an expression vector. Vector sequences were removed and the linearized construct was microinjected into fertilized eggs. These mice were crossed to C57BL/6JOlaHsd mice which lack alpha-synuclein as a result of a spontaneous deletion of the alpha-SNCA locus. Immunoblotting demostrated high levels of alpha-synuclein 1-120 in the nigrostriatal pathway and the olfactory bulb in the line 1 founder. (J:108310)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
