Log In|Sign Up
EN
The Camk2a promoter drives the expression of a truncated human DISC1 open reading frame that produces amino acids 1 through 597. This truncated protein is thought to function as a dominant negative. The transgene is expressed preferentially in neonatal stages, especially in pyramidal neurons of the dentate gyrus, and does not interfere with endogenous gene expression from Disc1. This is the low expressing line. (J:124683)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
